Glucorein: Can Coffee Really Be Good For PCOS?

by Becky Miller on January 4, 2013

Screen%20shot%202013 01 04%20at%202.47.53%20PM Glucorein: Can Coffee Really Be Good For PCOS?PCOS Weight Loss

We sure do love our coffee, don’t we? I mean, America practically runs on the stuff. This summer, a new supplement was being marketed towards women with PCOS and the company is currently running a “Baby Contest.” Its a campaign to hear stories of women with PCOS who have conceived using Glucorein, which is the subject of this post. Fertility and PCOS weight loss are big issues with PCOS so I was intrigued at how a supplement with coffee could be good for PCOS. 

Let me start by reminding you that as with any PCOS supplement or medication, they should be considered for what they are, supplements. So, in addition to a lifestyle of healthy activity and diet, these types of supplements can have positive effects for women with PCOS. Always consult your physician before beginning or stopping any medication or supplement.

When I first heard about Glucorein I was immediately skeptical at what health benefits could be had from a coffee bean. So, I did a little research and here’s what I found.

What Is Glucorein?

Glucorein is a natural supplement that was originally created for the dietary management of diabetes and is being marketed by Napa Valley Nutritionals. Knowing that diabetes and PCOS are closely related, the company began it’s campaign towards women with PCOS. I think you’ll be interested to see the results of my research for all women with PCOS, and especially those trying to conceive (TTC) with PCOS. There are only four total ingredients & two of those, active & natural ingredients that make up Glucorein.

  • Chlorogenic acid is the key active ingredient in the medical beverage. Chlorogenic acid is a derivitive extract of the Robusta green coffee bean. This is important because it contains nearly twice the amount of chlorogenic acid as the commonly consumed Arabica coffee. It has been ‘proven to minimize glucose uptake in the small intestine and shift the site of glucose absorption, which is in turn associated with a lower risk type 2 diabetes.’(1) In lamens terms, chlorogenic acid will slow the release of glucose into the blood stream, which also has an anti-obesity effect. This in turn has positive properties for insulin regulation and craving control. Chlorogenic acid is the chief compound that mediates this activity because of it’s properties as a vitamin B3 precursor.
  • L-Cysteine or N-acetyl-cysteine (NAC) is the second active ingredient in Glucorein. L-Cysteine is a naturally occuring amino acid that is responsible for the ‘induction of ovulation and can improve pregnancy rates in PCOS patients.’ (2) In this study, 180 infertile PCOS patients were given NAC for 5 days starting at day 3 of the cycle. The patients were measured after the 16th day and the number of follicles, ovulation (49.3%) and pregnancy (21.3%) rates were significantly higher than the placebo group. NAC has recently been heralded for its comparitive effects to metformin and clomid on insulin regulation and increased fertility markers.
  • Stevia & Monk Fruit are included to provide natural sweetness without added calories or blood sugar spikes. The monk fruit, also known as luo hand guo, is packed with antioxidants and vitamins especially vitamin C. It gets it’s name from the fact that it was harvested in 13th century China by the monks. The stevia is a complement to the monk fruit and is also incorporated to add a sweeter taste. I was intrigued to find a (4) studythat shows stevia has ‘revitalizing effects on pancreatic B-cells, possibly improving insulin sensitivity and promoting additional insulin production-all helping to reverse diabetes and metabolic syndrome.’
  • Cranberry & lemon fruit solids are simply included for flavoring. Both are also known for their detoxification and cleansing effects.

What Else Does It Do?

Glucorein also touts that, in addition to the above mentioned effects, the active ingredients will also decrease free testosterone levels and regulate menstrual cycles.

The NAC in Glucorein has “comparable effects to metformin on hyperandrogenism and menstrual irregularity.” (3) This study was performed on 100 women with PCOS who were given NAC three times daily for 24 weeks. It also shows that NAC “led to a significant decrease in total cholesterol and low-density lipoprotein levels.” That’s good news for our lipid profiles.

As if that weren’t good enough, hirsutism scores were also positively affected in this study.

How Does It Work?

Glucorein is a natural cranberry and lemon drink that comes in single serve packets of 30 per box. They are simply mixed with cold water once a day. The market research indicates that patients should consume Glucorein for 2-4 months before seeing maximum symptom relief.

Each box of 30 single serve packs runs for $67.50 and you must obtain Becky Miller’s Clinician Code to purchase Glucorein, as it must be used under the care of a certified health professional. Contact becky at

Bottom Line

I’m optimistic about the positive effects of Glucorein for PCOS patients. I have not personally tried the supplement, but know  women with PCOS who have and seem to ‘feel better’ taking Glucorein. The positive effects seem to be elevated in women who are following a proper PCOS diet with the help of CROWN Meal Plans and incorporating a plan or program to assist them in treating their PCOS.

If you’re interested in learning more about how Glucorein can be helpful to you, contact Becky for a free and complete nutritional evaluation.


(1) “Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.” Diabetes Care. 2009 Jun;32(6):1023-5. Epub 2009 Mar 26.

(2) “N-Acetylcystein as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovarian syndrome.” Journal of Obstetrics and Gynaecology Research. 2012 Sep;38(9):1182-6. Epub 2012 Apr 30.

(3) “Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome.” European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011 Nov;159(1):127-31. Epub 2011 Aug 9.

(4) “Stevia (Stevia rebaudiana) a bio-sweetener: a review.” International Journal of Food, Science & Nutrition. 2010 Feb;61(1):1-10. Epub 2010 Feb 6.

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